I remember all the debates about Topaz AI adding made up data, and real photographers would never use it. Despite that I've used Topaz Denoise AI and Topaz Photo AI quite a bit, almost always successfully (and now and then a case where it doesn't do a good job, it can throw away data it thinks is noise). I've not used DxO, or the DxO Lightroom plugin, so I can't compare it, but I will be doing some comparisons with the new Adobe Lightroom AI capability. A problem with Topaz is that it still doesn't accept S5II raw and you need to use the TIFF conversion path in Lightroom. This might give a slight advantage to the Lightroom version; but Topaz and DxO have a huge lead in denoise AI.